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Indications

Important Product Information

Indications

NeoVisc® HA 1.5% is indicated for treatment of pain and improvement of joint functionality in patients affected by degenerative (age-related changes) or mechanical arthropathy (related to overuse) of the knee.2

Relevant warnings and precautions2

Do not use in case of package damage.

Do not use the product after the expiry date reported on the package.

The expiry date refers to the product kept in its original package at a temperature not exceeding 25° C.

The syringe is for single use, which means it should be used once only for a single patient. Inject the contents in one joint only.

For the first 24 hours after injection, the patient is permitted to continue all routine activities of daily living but is recommended not to overuse the treated joint.

The assembled syringe must be discarded immediately after use, regardless of whether the solution has been completely administered.

If this product is reprocessed and/or reused, Fidia Farmaceutici cannot guarantee performance, functionality, material structure, cleanliness or sterility of the product.

Reuse could lead to illness, infection and/or serious injury to the patient or user.

After use, dispose according to applicable national practice. Keep out of reach of children.

Contraindications2

Do not administer to patients with ascertained individual hypersensitivity to the product components.

Do not administer in cases where there are infections or skin diseases in the area of the injection site.

Do not administer to patients with active synovitis.

Dosage and Administration2

NeoVisc®+ 3 X 2 mL
Cycles of 2 mL at weekly intervals for 3 weeks.

NeoVisc® ONE 4 mL
Single intra-articular injection, may be repeated at or after 6 months.

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What is NeoVisc?

NeoVisc is a gel-like substance manufactured from hyaluronic acid that is injected directly into your knee joint by your doctor. It is a naturally derived product made by biofermentation.

With knee OA, your knee joint fluid does not contain enough hyaluronic acid, which leads to pain and join stiffness. NeoVisc acts as a lubricant and a shock absorber in the knee joint, enabling it to work properly.2

NeoVisc relieves the pain of knee OA and improves mobility so you can get back to your favourite activities.3

Treatment Options

NeoVisc has been proven to provide long-lasting relief of OA knee pain.1 Everyone responds differently, but in a medical study, more than 90% of patients experienced pain relief starting two weeks after the third treatment with NeoVisc+, when it was injected once a week for three weeks.4

NeoVisc ONE

NeoVisc ONE is a single injection into the knee joint. The treatment may be repeated every 6 months as needed, to maintain the benefits over time.2

NeoVisc+

NeoVisc+ is injected into the knee joint once a week for three weeks, and you may repeat the treatment if needed to maintain the benefits over time.2
To develop the best treatment plan for your knee OA, it is important that your doctor knows how you are feeling and how your joint pain is affecting your everyday life.

What Treatments are Available for
Knee OA?

Although there is no cure for OA, there are many ways to manage your symptoms and pain. Your doctor can help to determine the best approach for you.

Treatments for mild knee OA

There are OA management options that do not involve medications or surgery. For mild OA symptoms, your doctor may recommend physical activity or a weight-loss program.5

Treatments for severe knee OA

For more severe knee OA, your doctor may advise taking prescription medications or non-prescription pain relievers such as acetaminophen, ibuprofen, or naproxen sodium.6 Other options include knee injections with hyaluronates2 or corticosteroids, or your doctor may recommend surgery.6

About Osteoarthritis

OA is a degenerative disease that causes cartilage to break down. Gradually, the surface of the cartilage is lost, especially in weightbearing joints, such as the knee joints.

The knee joint is a sophisticated joint that bears the body weight and allows for movement. There are various structures in the knee that together provide support and flexibility.

In severe OA, the cartilage can become so thin that it can no longer cover the thickened bone ends, resulting in injury to bone.7

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Healthy Knee Joint8

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Knee Joint With Osteoarthritis8

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What Causes Knee OA?

The cause of knee OA is unknown, but there are several factors that can increase the likelihood of developing the disease, including genes or family history, previous injuries, or being overweight. In some cases, sport-related injuries or a very active lifestyle can contribute to the development of knee OA. OA also becomes more common with age.9
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What Are the Symptoms of Knee OA?

Early symptoms of knee OA include pain while moving, standing, or sitting. The pain may become worse with exercise and go away when resting. You may also notice stiffness, swelling and redness, and over time the knee joint becomes less flexible. Some people with OA experience a grating sensation in the knee during movement.10

Symptoms are often painful and frequent, but with proper treatment they can be managed.9

Information for Patients

NeoVisc may not be suitable for everyone. Talk to your doctor if you have questions regarding NeoVisc, or for more information on pain associated with knee OA.

Please consult the Instructions for Use for important information about contraindications, precautions, adverse reactions, drug interactions, dosing and directions for use.

You can also call 1-866-391-4503 to get a copy of the Instructions for Use.

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Patient Guide

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Patients Guide FR

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Contact Us

We welcome your questions about our Company and our operations.
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References

1. Ojog S. Clinical evidence of knee osteoarthritis treatment with 2000 KDa HA up to 12 months. 4th International Symposium Intra Articular Treatment. (ISIAT) Budapest 1-3 October 2015.

2. NeoVisc®+ and NeoVisc® ONE Instructions for Use. September 2020.

3. Schieb F. Intra-articular injections of hyaluronic acid in the treatment of arthropathies. Arthritis & Rheuma. 2003;23:338-340.

4. Foti C, Cisari C, Carda S, et al. A prospective observational study of the clinical efficacy and safety of intra-articular sodium hyaluronate in synovial joints with osteoarthritis. Eur J Phys Rehabil Med. 2011;47:1-9.

5. Arthritis Society. Osteoarthritis self-management. https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/osteoarthritis/osteoarthritis-self-management. Accessed November 3, 2022.

6. Arthritis Society. Osteoarthritis treatment. https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/osteoarthritis/osteoarthritistreatment. Accessed November 3, 2022.

7. Arthritis Society. What is arthritis? https://arthritis.ca/about-arthritis/what-is-arthritis. Accessed November 3, 2022.

8. Osteoarthritis Research Society International (OARSI). What is osteoarthritis? https://oarsi.org/what-osteoarthritis. Accessed November 3, 2022.

9. Arthritis Society. Osteoarthritis. https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/osteoarthritis. Accessed November 3, 2022.

10. Arthritis Society. Osteoarthritis symptoms and diagnosis. https://arthritis.ca/about-arthritis/arthritis-types-(a-z)/types/osteoarthritis/osteoarthritis-symptoms-and-diagnosis. Accessed November 3, 2022.